Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.
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In general, phenothiazines are contraindicated in patients with liver damage.
In addition, serotonin syndrome may occur during use of tramadol with medications that impair its metabolism. Increased Mortality in Elderly people with Dementia. Moderate Concurrent use of tramadol and fluphenazine should be avoided if possible.
If a phenothiazine and carbamazepine must be used together, dosage adjustments of the phenothiazine may be required. In general, phenothiazines should be avoided in patients requiring therapy for Parkinson’s disease unless the benefit of the antipsychotic outweighs the risk of decreased therapeutic response to levodopa or phenothiazines.
Drug inhibits cough reflex, and aspiration may occur.
Modecate Injection 25mg/ml – Summary of Product Characteristics (SmPC) – (eMC)
Clarithromycin is associated with an established risk for QT prolongation and TdP, while fluphenazine a phenothiazine is associated with a possible risk for QT prolongation. Major Close monitoring is advisable during concurrent use of molindone with other antipsychotics. Concomitant administration of mitotane and CNS depressants, including opiate agonists, may cause additive CNS effects. Marketing authorisation insedt 8. Use fluphenazine with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including cardiac arrhythmias, congenital long QT syndrome, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to inserrt the QT interval or cause electrolyte imbalances.
Regulate body temperature as needed.
Modecate Injection 25mg/ml
Mefloquine alone has not been reported to cause QT prolongation; however due to the inxert of clinical data, mefloquine should be used with caution in patients receiving drugs that prolong the QT interval. According to the American Psychiatric Association treatment guidelines for schizophrenia, consider pregnancy testing in women of childbearing potential prior to initiation of insrt antipsychotic.
Transient abnormalities of liver function tests may occur in the absence of jaundice. Minor Chloroquine administration is associated with an increased risk of QT prolongation and torsades de pointes TdP.
Patients should take care and use proper techniques to limit sunlight and UV exposure. Dexmethylphenidate blocks central dopamine reuptake, which has the potential to exacerbate psychosis, and antipsychotics, which are central dopamine antagonists, may diminish the effectiveness of dexmethylphenidate.
Minor Phenothiazines may cause additive photosensitization with quinolones.
Drugs with a possible risk for QT prolongation that should decanlate used cautiously and with close monitoring with itraconazole include fluphenazine. Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as meclizine, a sedating H1-blocker. Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as dimenhydrinate, a sedating H1-blocker.
Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Phenothiazines may impair body temperature regulation. Insery Estradiol; Norethindrone Acetate: Administration of artemether; lumefantrine is associated with prolongation of the QT interval. Liver disease Renal impairment Cardiac arrhythmias, cardiac disease Thyrotoxicosis Severe respiratory disease Epilepsy, conditions predisposing to epilepsy eg.
Glasdegib therapy may result in QT prolongation and ventricular arrhythmias including ventricular fibrillation and ventricular tachycardia. If NMS is diagnosed, immediately discontinue deutetrabenazine, and provide intensive symptomatic treatment and medical monitoring.
These effects have varied in severity from self-limited to requiring intensive care unit stays and prolonged hospitalization. Minor Coadministration of fluphenazine and eliglustat may result in increased concentrations of the phenothiazine and, theoretically, an increased risk of QT flpuhenazine.
Minor Halogenated anesthetics should be used cautiously decnoate with close monitoring with fluphenazine. Discard markedly discolored solutions. The possibility of a suicide attempt is inherent in patients with symptoms of depression concomitantly with other psychoses. Not recommended for children.